The tumor microenvironment (TME) systems in precision medicine symposium will center on translational research related to TME, connecting it to clinical trials and entrepreneurship. While conventional anti-cancer therapies were primarily designed to target the inherent properties of tumor cells; research indicates that both nearby and distant cells surrounding the tumor play a crucial role in treatment effectiveness. The fundamental questions revolve around the identification and intentional manipulation of TME compositions and structures to develop anti-tumor environments that enhance targeted tumor therapies. The symposium will focus on innovative model systems, understanding the mechanisms of complex system behavior, and clinical investigations utilizing single-cell and spatial -omics technologies to study TME structure and function. Symposium speakers will analyze systems-based approaches, hypoxia, metabolic regulations, extracellular vesicles, antigenicity, lymph-node interactions, and how these factors predict treatment outcomes. While dominated by breast cancer research, the symposium will also cover other cancer types such as colon and lung cancer, melanoma, uveal melanoma, brain cancers, and acute myeloid leukemia.
Details
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus
Paul-Ehrlich-Straße 42-4460596 Frankfurt am Main
Germany
Program
Introduction to tumor microenvironment systems in precision medicine, Zuzana Tatarova
09:10 – 09:35 Eivind Egeland, Oslo University Hospital, Norway
Understanding Chemo-Resistance in Triple Negative Breast Cancer through PDX model systems
09:35 – 10:00 Colinda Scheele, VIB KU Leuven, Belgium
Tracing the dynamics of mammary tumor initiation using intravital imaging
10:00 – 10:30 Paloma Ordóñez-Morán, University of Nottingham, UK
Modeling the Extracellular Matrix of Colon Cancer Tumors Using Patient-Derived Organoids
10:30 - 11: 00 Coffee break
11:00 – 12:00 Joe W Gray, Oregon Health & Science University, Portland, OR, USA
Rethinking Precision Cancer Treatment for Advanced Cancers; A Systems Biomedicine Approach
12:00 - 1:30 Lunch break and poster session
13:30 – 13:55 Zuzana Tatarova, DKFZ/DKTK Georg-Speyer-Haus, Germany
Multiplex implantable microdevice assay to find the TME role in breast cancer therapy efficacy
13:55 – 14:20 Spencer Watson, University of Lausanne, Switzerland
Spatial multi-omics in glioblastoma recurrence
14:20 – 15:00 Chris Marine, VIB KU Leuven, Belgium
Monitoring and Mitigating Cancer Cell Plasticity to Overcome Therapy Resistance in Melanoma
15:00 – 15:20 Julia Frede, LMU Munich, Germany
Leveraging Single-Cell Technologies to Identify Novel (Immuno-) Therapeutic Opportunities in Cancer and Immune Cells
Coffee break and museum tour of the historical research site of Paul Ehrlich 3:20 - 5:00
09:10 – 09:50 Silvia Pastoreková, Slovak Academy of Science, Slovakia
The impact of hypoxia and acidosis on microevolution in tumor tissue
09:50 – 10:30 Cathrin Brisken, EPFL, Switzerland & Institute of Cancer Research, London, UK
Lost in translation? Models matter!
10:30 - 11: 00 Coffee break
11:00 – 11:40 Justin Balko, Vanderbilt University Medical Center, TN, USA
Antigen presentation deficiencies in the breast cancer microenvironment
11:40 – 12:10 Angela Riedel, University Hospital Würzburg, Germany
Understanding the link between immune evasion and metastasis: A story of stromal - immune cell interactions in tumor-draining lymph nodes
12:10 - 1:30 Lunch break
13:30 – 14:10 Ulrich Keller, Charité Berlin, Germany
Multi-omics to dissect cancer and its tumor microenvironment: from preclinical models to patient cohorts
14:10 – 14:50 Hubert Serve, University Medicine, Goethe University Frankfurt, Germany
Amino Acid Metabolism in AML
14:50 – 15:15 Lena Jassowicz, University Hospital Heidelberg, Germany
Single-cell mapping of human brain metastases reveals prognostically relevant immune landscapes
Wrap-up of the tumor microenvironment systems in precision medicine, Zuzana Tatarova
Museum tour of the historical research site of Paul Ehrlich 3:20 - 5:00
Posters
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1 |
Madhura Kulkarni |
Center for Translational Cancer Research, A joint institute between IISER Pune and Prashanti Cancer Care Mission |
Immune Profile Changes in Primary and Post-NACT tumor beds of BRCA1 mutant TNBC patients |
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2 |
Isidora Milislav |
Institute of Biotechnology of the Czech Academy of Sciences |
ENDOTHELIAL PYRIMIDINE SYNTHESIS DEFICIENCY PROMOTES TUMOR GROWTH |
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3 |
Eleni Lamprou |
EPFL-Agora Cancer Research Center |
Repurposing Tricyclic Antidepressants for Glioblastoma Treatment |
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4 |
Chun-Shan Liu |
German Cancer Research Center |
Distinct Tumor Microenvironment in Cholangiocarcinoma: Insights from a Syngeneic Mouse Model
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5 |
Arwin Groenewoud
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Friedrich-Alexander-Universität Erlangen-Nürnberg |
Unraveling tumor-microenvironmental communication in nascent bone metastasis using zebrafish |
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6 |
Yishu Xu |
DKTK/DKFZ & Georg Speyer Haus |
Triple Attack on Breast Cancer: Synergizing Targeted Therapies to Kill Tumor Cells and Activate Immune Responses |
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7 |
Simge Yucel |
EPFL-Agora Cancer Research Center |
MRP Upregulation in Cancer: Implicating FMRP-expressing Cancer-Associated Fibroblasts in Immune Evasion |
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8 |
Yu-Le Wu |
German Cancer Research Center |
Unraveling Subcellular Organization in the Tumor Microenvironment Using Multiplexed Imaging of Human Tissue |
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9 |
Reija Laitinen |
Bruker Spatial Biology |
A universal 6,000-plex RNA panel to construct comprehensive single-cell spatial atlases across multiple FFPE human tissues |
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10 |
Sherry Derakhshani |
Zeiss
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Enhancing Multiplex Immunofluorescence Workflows: An Automated Imaging Solution for Improved Efficiency and Reproducibility |
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11 |
Moritz Widmaier |
Zeiss
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Enhancing Spatial Biology with Kromnigon’s Streptaclick Technology and ZEISS Axioscan 7 |