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The tumor microenvironment (TME) systems in precision medicine symposium will center on translational research related to TME, connecting it to clinical trials and entrepreneurship. While conventional anti-cancer therapies were primarily designed to target the inherent properties of tumor cells; research indicates that both nearby and distant cells surrounding the tumor play a crucial role in treatment effectiveness. The fundamental questions revolve around the identification and intentional manipulation of TME compositions and structures to develop anti-tumor environments that enhance targeted tumor therapies. The symposium will focus on innovative model systems, understanding the mechanisms of complex system behavior, and clinical investigations utilizing single-cell and spatial -omics technologies to study TME structure and function. Symposium speakers will analyze systems-based approaches, hypoxia, metabolic regulations, extracellular vesicles, antigenicity, lymph-node interactions, and how these factors predict treatment outcomes. While dominated by breast cancer research, the symposium will also cover other cancer types such as colon and lung cancer, melanoma, uveal melanoma, brain cancers, and acute myeloid leukemia.

Details

Start: December 3, 2024
End: December 4, 2024
TMEsystems24@georg-speyer-haus.de Zuzana Tatarova

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus

Paul-Ehrlich-Straße 42-44
60596 Frankfurt am Main
Germany

Program

Agenda - Day 1
Agenda - Day 2
Day 1 – December 3rd, 2024
9:00 AM — 9:10 AM
WELCOME

Introduction to tumor microenvironment systems in precision medicine, Zuzana Tatarova

9:10 AM — 10:30 PM
NOVEL MODEL SYSTEMS

09:15 – 09:35    Eivind Egeland, Oslo University Hospital, Norway

                                Understanding Chemo-Resistance in Triple Negative Breast Cancer through PDX model systems

09:35 – 10:00    Colinda Scheele, VIB KU Leuven, Belgium

                                Tracing the dynamics of mammary tumor initiation using intravital imaging

10:00 – 10:30    Paloma Ordóñez-Morán, University of Nottingham, UK

                                Modeling the Extracellular Matrix of Colon Cancer Tumors Using Patient-Derived Organoids

10:30 - 11: 00 Coffee break

11:00 AM — 12:00 PM
KEYNOTE SPEAKER

11:00 – 12:00    Joe W Gray, Oregon Health & Science University, Portland, OR, USA

12:00 - 1:30 Lunch break and poster session

1:30 PM — 3:20 PM
SPATIAL/MULTI -OMICS

13:30 – 13:55    Zuzana Tatarova, DKFZ/DKTK Georg-Speyer-Haus, Germany

13:55 – 14:20    Spencer Watson, University of Lausanne, Switzerland

                                Spatial multi-omics in glioblastoma recurrence

14:20 – 15:00    Chris Marine, VIB KU Leuven, Belgium

15:00 – 15:20    Julia Frede, LMU Munich, Germany

                                Leveraging Single-Cell Technologies to Identify Novel (Immuno-) Therapeutic Opportunities in Cancer and Immune Cells

Coffee break 3:20 - 3:50

3:50 PM — 4:40 PM
INSIGHTS FROM SMALL COMPANIES

15:50 – 16:15    Raj Lehal, Switzerland

16:15 – 16:40    Daniela Paňková, Czech Republic    

Day 2 – December 4th, 2024
9:00 AM — 10:30 PM
FROM MECHANISM TO TRANSLATION

09:10 – 09:50    Silvia Pastoreková, Slovak Academy of Science, Slovakia

                              The impact of hypoxia and acidosis on microevolution in tumor tissue

09:50 – 10:30    Cathrin Brisken, EPFL, Switzerland & Institute of Cancer Research, London, UK

                              Lost in translation? Models matter!

10:30 - 11: 00 Coffee break

11:00 AM — 12:10 PM
FROM MECHANISM TO TRANSLATION II

11:00 – 11:40    Justin Balko, Vanderbilt University Medical Center, TN, USA

                             Antigen presentation deficiencies in the breast cancer microenvironment

11:40 – 12:10    Angela Riedel, University Hospital Würzburg, Germany

                             Understanding the link between immune evasion and metastasis: A story of stromal - immune cell interactions in tumor-draining lymph nodes

12:10 - 1:30 Lunch break

1:30 PM — 3:15 PM
INSIGHTS FROM CLINICS

13:30 – 14:10    Ulrich Keller, Charité Berlin, Germany

                              Multi-omics to dissect the tumor microenvironment in clinical cohorts

14:10 – 14:50    Hubert Serve, University Medicine, Goethe University Frankfurt, Germany

                              Tba

14:50 – 15:15    Lena Jassowicz, University Hospital Heidelberg, Germany

                              Single-cell mapping of human brain metastases reveals prognostically relevant immune landscapes

 

3:15 PM — 3:20 PM
WRAP UP

Wrap-up of the tumor microenvironment systems in precision medicine, Zuzana Tatarova

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